2017-08-23 来源:京师杏林考研网 分享到:
考研英语模拟题阅读
At 18, Ashanthi DeSilva of suburban Cleveland is a living symbol of one of the great intellectual achievements of the 20th century. Born with an extremely rare and usually fatal disorder that left her without a functioning immune system (the “bubble-boy disease,” named after an earlier victim who was kept alive for years in a sterile plastic tent), she was treated beginning in 1990 with a revolutionary new therapy that sought to correct the defect at its very source, in the genes of her white blood cells. It worked. Although her last gene-therapy treatment was in 1992, she is completely healthy with normal immune function, according to one of the doctors who treated her, W. French Anderson of the University of Southern California. Researchers have long dreamed of treating diseases from hemophilia to cancer by replacing mutant genes with normal ones. And the dreaming may continue for decades more. “There will be a gene-based treatment for essentially every disease,” Anderson says, “within 50 years.”
It's not entirely clear why medicine has been so slow to build on Anderson's early success. The National Institutes of Health budget office estimates it will spend $432 million on gene-therapy research in 2005, and there is no shortage of promising leads. The therapeutic genes are usually delivered through viruses that don't cause human disease. “The virus is sort of like a Trojan horse,” says Ronald Crystal of New York Presbyterian/Weill Cornell Medical College. “The cargo is the gene.”
At the University of Pennsylvania's Abramson Cancer Center, immunologist Carl June recently treated HIV patients with a gene intended to help their cells resist the infection. At Cornell University, researchers are pursuing gene-based therapies for Parkinson's disease and a rare hereditary disorder that destroys children's brain cells. At Stanford University and the Children's Hospital of Philadelphia, researchers are trying to figure out how to help patients with hemophilia who today must inject themselves with expensive clotting drugs for life. Animal experiments have shown great promise.
But somehow, things get lost in the translation from laboratory to patient. In human trials of the hemophilia treatment, patients show a response at first, but it fades over time. And the field has still not recovered from the setback it suffered in 1999, when Jesse Gelsinger, an 18-year-old with a rare metabolic disorder, died after receiving an experimental gene therapy at the University of Pennsylvania. Some experts worry that the field will be tarnished further if the next people to benefit are not patients but athletes seeking an edge. This summer, researchers at the Salk Institute in San Diego said they had created a “marathon mouse” by implanting a gene that enhances running ability; already, officials at the World Anti-Doping Agency are preparing to test athletes for signs of “gene doping.” But the principle is the same, whether you're trying to help a healthy runner run faster or allow a muscular-dystrophy patient to walk. “Everybody recognizes that gene therapy is a very good idea,” says Crystal. “And eventually it's going to work.”
1. The case of Ashanthi Desilva is mentioned in the text to ____________.
[A] show the promise of gene-therapy
[B] give an example of modern treatment for fatal diseases
[C] introduce the achievement of Anderson and his team
[D] explain how gene-based treatment works
2. Anderson‘s early success has ________________.
[A] greatly speeded the development of medicine
[B] brought no immediate progress in the research of gene-therapy
[C] promised a cure to every disease
[D] made him a national hero
3. Which of the following is true according to the text?
[A] Ashanthi needs to receive gene-therapy treatment constantly.
[B] Despite the huge funding, gene researches have shown few promises.
[C] Therapeutic genes are carried by harmless viruses.
[D] Gene-doping is encouraged by world agencies to help athletes get better scores.
4. The word “tarnish” (line 5, paragraph 4) most probably means ____________.
[A] affect
[B] warn
[C] trouble
[D] stain
5. From the text we can see that the author seems ___________.
[A] optimistic
[B] pessimistic
[C] troubled
[D] uncertain
答案:A B C D A
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在我快被考研数学虐哭时,是京师考研的老师们耐心的解答,一边边讲解知识点的帮助,让我渐渐增加了考研信心。衷心感谢网校老师!
学员:元元
这平台太给力了!不但能电脑听课,还可以用手机听课,用pad听课。解答问题也非常快速,最最重要的是非常非常负责任!顶起!
学员:17080116
课程讲解很详细,讲义也非常详细。听完课程,做做练习册,很容易就掌握了知识。京师考研的老师们辛苦啦!
学员:changqing
老师讲课很好,重点分明,层次很清楚,跟着老师学了一段时间,感觉自己复习起来思路也清晰了很多,很见功力,不愧是考研辅导界实力派老师!